Melaleuca alternifolia Cheel (Myrtaceae), Citrus limon (L.) Burm.f. (Rutaceae), Caryocar brasiliense Cambess (Caryocaraceae), Pelargonium graveolens L´Hér (Geraniaceae) and Propolis extract as in vitro Sporothrix schenckii inhibitors
DOI:
https://doi.org/10.46311/2178-2571.38.eURJ4620Palabras clave:
Essential oils, phytotherapy, Sporotrichosis.Resumen
Sporotrichosis, a mycosis caused by fungus of the genus Sporothrix, has the itraconazole therapy of first choice. Resistance reports have been observed to both Itraconazol and amphotericin B, culminating in treatment failures and clinical cases like pulmonary or systemic infections. The aim of this study was to evaluate in vitro the effect of essential oils from Melaleuca alternifolia Cheel (Myrtaceae), Citrus limon (L.) Burm.f. (Rutaceae), Caryocar brasiliense Cambess (Caryocaraceae), Pelargonium graveolens L´Hér (Geraniaceae) and pure propolis extract or associated in inhibiting of S. schenckii growth. The methods used were Kirb-Bauer, disk diffusion on agar, Minimum Inhibitory Concentration and Minimum Fungicide Concentration. The essential oils and the propolis extract were effective in inhibiting fungal growth, overcoming the effects of itraconazole. Itraconazole was able to inhibit the growth of S. schenckii up to a dilution of 4mg.mL-1 (10-3 dilution). The essential oils of melaleuca, geranium, lemon, all at a concentration of 10mg.mL-1 and propolis extract at a concentration of 20mg.mL-1, were able to inhibit, respectively, the development of this fungus at concentrations lower than 0.325mg.mL-1 (10-6 dilution), 0.15625mg.mL-1 (10-7 dilution), 0.325mg.mL-1 (10-4 dilution) and 0.625mg.mL-1 (10-6 dilution). Geranium and melaleuca essential oils showed the best inhibition and fungicidal potential against S. schenckii. These results suggest the importance of in vivo tests to evaluate the use of these herbal medicines as an alternative treatment against sporotrichosis.
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Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
I declare/we declare that the text submitted here is original, of my own authorship and does not infringe any type of third party rights. The content is my/our sole responsibility. Possible research involving animals and/or human beings is in accordance with Resolution 196/96 of the National Health Council and its complements. I declare that I am/we are in possession of the written consent of patients and that the research and its procedures were timely and adequately approved by the Ethics Committee of the institution of origin. We further declare that all institutional affiliations and all sources of financial support for the work are duly informed. I certify that there is no commercial or associative interest that represents a conflict of interest related to the submitted work. If there is commercial interest, in addition to the technical and academic ones, in the publication of the article, the information will be reported during the text.
