Multiple sclerosis and the relation to the excessive consumption of sodium chloride: a systematic review

Abstract

Multiple Sclerosis is an autoimmune disease demyelinating which affects mainly the central nervous system, because it is influenced by genetic and environmental factors. This research aims to point the relationship between sodium chloride consumption and the likely triggering and/or worsening of Multiple Sclerosis (MS), an autoimmune disease. The selected articles were analyzed according to the systematic literature review to ascertain the possible relationship between the worsening of the pathophysiology of multiple sclerosis and the consumption of sodium chloride. The systematic literature review followed the following databases: BVS, Science Direct, PUBMED, and Web of Science. From the articles found, a previous selection was made, in which 13 articles were selected, based on keywords related to sodium chloride and multiple sclerosis, referring to studies made in vitro and in vivo. It has been demonstrated the relationship between MS physiopathology and the overconsumption of salt is negative in five research and positive in others.  Thus, despite the favorable results, indicating the relationship between sodium consumption and Multiple Sclerosis, further research is suggested, due to the diversity of methodology and populations used in each study.