Desenvolvimento e validação de metodologia para a certificação da pureza enantiomérica do Efavirenz
DOI:
https://doi.org/10.46311/2318-0579.2.eUJ360Abstract
Uma metodologia simples, por CLAE (Cromatografia Líquida de Alta Eficiência)
quiral, foi desenvolvida e validada para a determinação da pureza enantiomérica do
efavirenz. A metodologia foi desenvolvida utilizando-se uma coluna quiral com fase
tris[(S)-1-feniletilcarbamato] de amilose, no modo reverso de eluição utilizando
ACN/H2O (53:47 v/v) como fase móvel. A metodologia desenvolvida pode ser utilizada
na indústria farmacêutica para análises de rotina e certificação de matéria-prima e
produto acabado.
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