MORPHOLOGICAL CHANGES IN BRAINS OF PEOPLE DIAGNOSED WITH DEPRESSION: INTEGRATIVE LITERATURE REVIEW
Keywords:Anatomy, Brain, Depression, Diagnosis, Neuroimaging
According to the World Health Organization (WHO), depression is a common disorder that has grown exponentially worldwide, with an estimated over 300 million people affected by this condition, which makes it a public health problem. Among the consequences, we highlight the impairment of daily and social activities of individuals in all age groups, which can cause tragic outcomes and risk of life. The present study aims to study the morphological changes in the brains of people diagnosed with depression. For that, an integrative literature review was carried out in the data bases Scielo and Medline. After careful reading, five articles were selected that met the inclusion criteria. The analysis showed that the brains of people diagnosed with depression show visible changes in neuroimaging tests, such as magnetic resonance imaging. The identified changes weresmaller subcortical volumes, larger ventricular volumes, lower volume of gray matter in the orbitofrontal cortex, abnormality in the prefrontal cortex, loss of differentiation between white and gray matter and involvement of limbic structures. The study showed, therefore, that neuroimaging exams can present themselves as an important resource for obtaining a faster and more accurate diagnosis of this pathology.
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